Endocrine Abstracts

MicroRNAs (miRNAs) negatively regulate gene expression and it is estimated that at least 30% of all protein encoding genes are controlled by miRNAs at the post-transcriptional level. While it is clear that miRNAs both inhibit translation and decrease mRNA stability whether these pathways act in parallel or occur in an ordered sequence of events remains unknown. Using well characterised viral IRESs we show that miRNAs require translational repression and in its absence, gene si...